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基因表达产品
℡ 4000-520-616
℡ 4000-520-616
Zyagen/TLR-3 Recombinant Protein/7953/1 Ea
产品编号:7953
市  场 价:¥2940.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$147.00
品      牌: Zyagen
公      司:Zyagen
公司分类:
Zyagen/TLR-3 Recombinant Protein/7953/1 Ea
商品介绍

Background

TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-?B pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

 

Specifications

Additional Names
Toll-like receptor 3; CD283 antigen
Preparation
Biological activity was determined by its ability to inhibit IL - 8 secretion induced by Poly I:C in the TLR3 receptor - expressing HEK293 cells (HEK293 TLR3r).The ED50 for this effect is ? 30 μg/ml in the presence of 100 μg/ml of Poly I:C.
Location
STTKCTVSHE VADCSHLKLT QVPDDLPTNI TVLNLTHNQL RRLPAANFTR YSQLTSLDVG FNTISKLEPE LCQKLPMLKV LNLQHNELSQ LSDKTFAFCT NLTELHLMSN SIQKIKNNPF VKQKNLITLD LSHNGLSSTK LGTQVQLENL QELLLSNNKI QALKSEELDI FANSSLKKLE LSSNQIKEFS PGCFHAIGRL FGLFLNNVQL GPSLTEKLCL ELANTSIRNL SLSNSQLSTT SNTTFLGLKW TNLTMLDLSY NNLNVVGNDS FAWLPQLEYF FLEYNNIQHL FSHSLHGLFN VRYLNLKRSF TKQSISLASL PKIDDFSFQW LKCLEHLNME DNDIPGIKSN MFTGLINLKY LSLSNSFTSL RTLTNETFVS LAHSPLHILN LTKNKISKIE SDAFSWLGHL EVLDLGLNEI GQELTGQEWR GLENIFEIYL SYNKYLQLTR NSFALVPSLQ RLMLRRVALK NVDSSPSPFQ PLRNLTILDL SNNNIANIND DMLEGLEKLE ILDLQHNNLA RLWKHANPGG PIYFLKGLSH LHILNLESNG FDEIPVEVFK DLFELKIIDL GLNNLNTLPA SVFNNQVSLK SLNLQKNLIT SVEKKVFGPA FRNLTELDMR FNPFDCTCES IAWFVNWINE THTNIPELSS HYLCNTPPHY HGFPVRLFDT SSCKDSAPFE L
Source
293 cells
Reactivity
n/a
Tested Application
n/a
Storage
The lyophilized TLR-3 recombinant protein is stable for at least 2 years from date of receipt at -20ËšC. Reconstituted TLR-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20ËšC. As with any protein, exposing TLR-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Species Reactivity
n/a
Purity
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

 

品牌介绍
  • Zyagen Laboratories
    ◆发表日期:2012-4-30
      

     

    Zyagen Laboratories

    美国Zyagen Laboratories公司位于加利福尼亚州的生物硅谷圣地亚哥,是一家著名的提供基因表达产品和服务的生物公司。从2000年到现在,在基因表达方面的研究及产品的推广一直处于全球领先地位。Zyagen Laboratories公司由一批训练有素的高水平的学者与研究人员,同时与发展中国家的科学家在生物制药,生物技术等方面有着广泛的合作。

    Zyagen Laboratories公司开发和生产销售细胞定位,基因表达及其蛋白质产物的定量分析的生命科学研究产品。Zyagen Laboratories也提供组织学和药物分析等与政府和学术机构合作的全球定制研究服务。Zyagen公司正在不断改进和扩大产品和服务线,以满足越来越多的科学家在生物医学、生命科学研究的需求。Zyagen公司的目标是致力提供简单化、完整化,高质量,价格实惠的基因表达产品及服务。

    官方网址:http://www.zyagen.com

    咨询与订购:苏州蚂蚁淘生物科技有限公司 免费电话:4000-520-616

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