Background
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant human Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (192 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Manufactured under license from the University of Washington patent# US 6,716,600; US 6,692,943; US 6,645,937; US 6,403,335; US 6,232,449; US 6,222,022.
Specifications
- Zyagen Laboratories
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◆发表日期：2012-4-30
Zyagen Laboratories
美国Zyagen Laboratories公司位于加利福尼亚州的生物硅谷圣地亚哥，是一家著名的提供基因表达产品和服务的生物公司。从2000年到现在，在基因表达方面的研究及产品的推广一直处于全球领先地位。Zyagen Laboratories公司由一批训练有素的高水平的学者与研究人员，同时与发展中国家的科学家在生物制药，生物技术等方面有着广泛的合作。
Zyagen Laboratories公司开发和生产销售细胞定位，基因表达及其蛋白质产物的定量分析的生命科学研究产品。Zyagen Laboratories也提供组织学和药物分析等与政府和学术机构合作的全球定制研究服务。Zyagen公司正在不断改进和扩大产品和服务线，以满足越来越多的科学家在生物医学、生命科学研究的需求。Zyagen公司的目标是致力提供简单化、完整化，高质量，价格实惠的基因表达产品及服务。
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